职称：教授

邮件： Luoyx@hunnu.edu.cn

通讯地址：湖南省长沙市岳麓区桐梓坡路371号湖南师范大学医学院

个人简介：

罗宜孝教授，博导，长期从事情感与认知障碍相关精神疾病的发病机制与防治策略研究，重点关注药物成瘾、PTSD及抑郁症。主持及参与国家自然科学基金10余项。以第一作者或通讯作者（含共同）在Science、Neuron、Nature Communications、Advanced Science等期刊发表SCI论文50余篇。任中国毒理学会药物依赖性毒理学专业委员会第七届委员会委员；中国药物滥用防治协会成瘾与脑科学分会委员；中国神经科学学会睡眠与生物节律分会第一届委员会常务委员。

主持课题：

1、国家自然科学基金面上项目 (82271534)：杏仁核mTOR信号通路在非条件性刺激诱导的药物成瘾记忆再巩固中的作用及机制，1/1/2022-12/30/2025，52万。

国家自然科学基金面上项目 (81771434)：eIF2α-ATF4信号通路在非条件性刺激诱导的病理性情感记忆再巩固中的作用及神经机制，1/1/2018-12/30/2020，54万。

2、国家自然科学基金青年项目(81501150) ：应激在非条件性刺激诱导的药物奖赏记忆再巩固中的作用及神经机制，，1/1/2016-12/30/2018，17.5万。

3、“湖湘青年英才”人才支持计划，2017年，50万。

4、长沙市“杰出创新青年”培养计划，2019年，50万。

5、湖南省自然科学基金青年项目（2016JJ3093）：BLA脑区eIF2α磷酸化在非条件性刺激诱导的成瘾记忆再巩固中的作用。23/5/2016.5-23/5/2019，5万。

6、湖南师范大学博士启动基金，环状RNA在病理性情感记忆中的作用及其表观调控机制，1/1/2015-12/30/2020,150万。

近五年代表性学术论文(*第一作者, #通讯)：

1. Zu-Cheng Shen, Yu-Xuan Weng, Zhi-Xuan Xia, Yue-Ling Zhao, Qian-Qian Ding, Si-Ying WangTing Cao, Xuan-Ying Chen, Wu-Cheng Tao, Shen Lin#, Zhou Chen#, Yi-Xiao Luo# ."Palmitoylation of PSD-95 Orchestrates Learning-Dependent Metaplasticity in the Amygdala and Fear Memory." Advanced Science (2026): e76302.

2. Tian, Yu, Yutong Liu, Haiyang Jing, Cuijie Shi, Yao Li, Shiyu Dong, Long Li, Bingchen Chen, Yanming Chen, Jufang He, Yixiao Luo#, Zijun Chen#, and Yingjie Zhu#. "A Septal Inhibitory Circuit Constrains Alcohol Reward and Mediates Liraglutide’s Suppressive Effects on Alcohol Intake in Mice." Neuron (2026).

3. Wang, Jian, Minglong Zhang, Linyi Qiao, Yeneng Pu, Yufei Sun, Xiaorui Su, Rongji Hui, Ludi Zhang, Bing Xie, Bin Cong, Yixiao Luo#, Chunling Ma#, and Di Wen#. "CCK2R Regulates METH-induced CPP Acquisition Within VTA-BLA-BNST Circuit in Male Mice." Translational psychiatry (2026).

4. Huang, Shihao, Zhihao Song, Cuijie Shi, Dan Tao, Jing Wen, Yisi Chen, and Yixiao Luo#. "A Single Extinction-Based Treatment with N-Acetylcysteine Produces Long-Term Reduction in Cocaine Relapse." Translational psychiatry (2026).

5. Shuting Luo, Zihan Qi, Feilong Wu, Dan Tao, Shihao Huang, Cuijie Shi, Chang Yang, Yan Shi#, Yixiao Luo#. Flavokawain B ameliorates depressive-like behaviors by inhibiting neddylation in the ventral hippocampus. Neuropharmarmacology (2025).

6. Dan Tao，Shihao Huang, Zhihao Song, Jing Wen, Ewa Galaj, Yixiao Luo#. Regulation of Addiction by the Insular Cortex: The Interplay Between Interoception and Cognitive Function. iScience (2025).

7. Shihao Huang, Zhihao Song, Cuijie Shi, Dan Tao, Jing Wen, Yisi Chen, Yixiao Luo#. A Single Extinction-Based Treatment with N-Acetylcysteine Produces Long-Term Reduction in Cocaine Relapse. Translational Psychiatry (2025).

8. Shihao Huang, Zhihao Song, Jiayue Pan, Yixiao Luo#, Yun Chen#.The emerging role of Circular RNAs in Neuropsychiatric Disorders. Translational Psychiatry, (2025).

9. Huang S, Liu X, Li Z, Si Y, Yang L, Deng J, Luo Y#, Xue YX#, Lu L#. Memory Reconsolidation Updating in Substance Addiction: Applications, Mechanisms, and Future Prospects for Clinical Therapeutics. Neurosci Bull. (2025).

10. Cao T, Tian D, Wang SY, Pan Y, Xia ZX, Chen WK, Yang SW, Zeng QQ, Zhao YL,Zheng L, Li N, Lai ZM#, Luo YX#, Shen ZC#. Microglial DBP Signaling Mediates Behavioral Abnormality Induced by Chronic Periodontitis in Mice. Adv Sci(Weinh), (2024) .

11. Huang S, Shi C, Tao D, Yang C, Luo YX#. Modulating reward and aversion:Insights into addiction from the paraventricular nucleus. CNS Neurosci Ther, (2024 ).

12. Shi C, Qi Z, Yang C, Luo S, Huang S#, Luo Y#. Shikonin ameliorates depressive-and anxiogenic-like behaviors in rats via the suppression of inflammation in the hippocampus. Neurosci Lett. (2024).

13. Yang H, Zhang X, Zhang M, Lu Y, Xie B, Sun S, Yu H, Cong B, Luo Y#, Ma C#, Wen D#. Roles of lncLingo2 and its derived miR-876-5p in the acquisition of opioid reinforcement. Addict Biol.( 2024).

14. Antidepressant effect of teriflunomide via oligodendrocyte protection in a mouse model. Shuting Luo, Feilong Wu, Qian Fang, Yue Hu, Huihui Zhang, Shishan Yuan, Chang Yang, Yan Shi#, Yixiao Luo# , Heliyon, (2024).

15. Roles of nucleus accumbens shell small-conductance calcium-activated potassium channels in the conditioned fear freezing. Minglong Zhang*, Yixiao Luo*, Jian Wang, Yufei Sun, Bing Xie, Ludi Zhang, Bin Cong, Chunling Ma, Di Wen#, Journal of Psychiatric Research, (2023).

16. Yixiao Luo*, Penghui Zhao*, Mengxiao Dou*, Jiawen Mao, Ge Zhang, Yujiao Su, Qingqun Wang, Qian Wang, Yurun Wang, Ruoxuan Sun, Tingxuan Liu, Miao Gong, Yuan Gao, Xi Yinb#, Li Song#, Haishui Shi#. Exogenous microbiota-derived metabolite trimethylamine N-oxide treatment alters social behaviors: Involvement of hippocampal metabolic adaptation.  Neuropharmacology,(2021).

15. Exogenous SO2 donor treatment impairs reconsolidation of drug reward memory in mice. Ding Rulan*, Yang Zhenbang*, Zhang Yipu*, Gao Yuan, Ewa Galaj, Shi Xiaorui, Li Wenshuya , Luo Jiaqi, Zhang Yan, Yang Chang, Yin Xi, Song Li, Luo Yixiao#, Shi Haishui# European Journal of Pharmacology,(2021).

16. Atractylenolide III reduces depressive- and anxiogenic-like behaviors in rat depression models. Yu Zhou, Shihao Huang, Feilong Wu, Qiuyao Zheng, Fushen Zhang, Yixiao Luo#, Xiaohong Jian#, Neuroscience Letters,(2021).