名字：Berthold Hocher

照片：

职称：教授

职务：教师

专业：病理学与病理生理学

联系电话：

电子邮箱：Berthold.Hocher@medma.uni-heidelberg.de

实验室主页（可选）：

传真（可选）：

通讯地址：湖南师范大学医学院

简介：

Berthold Hocher，德国籍，教授。现为湖南师范大学医学院“外专百人计划”讲座教授，德国海德堡大学曼海姆医学院肾病内分泌与风湿科教授。Hocher教授是国际上知名的心血管-肾病学研究专家，是欧洲最早从事健康与疾病的发育起源学说的研究专家之一。Hocher教授担任Journal of Hypertension等杂志学术编委。至今已获得德国自然科学研究基金5项， 欧洲研究基金1项，Fressenius研究基金4项，多项企业合作基金等资助，已获得多项欧洲及美国专利，已发表SCI收录的文章280篇，总IF:1039.2,总引用次数：5126，总H-指数：38。

社会（学术）兼职：

1.瑞士伯恩大学客座教授

2.德国柏林洪堡大学夏立特医学院心血管研究中心/药理学研究所（CCR）客座教授

3.勃林格殷格翰医药集团顾问

4.荷兰Wijchen公司顾问

5.欧洲高血压与肾脏病等学会委员

6.德国国家科学基金等资助申请评审员

所获奖励（荣誉）：

由于HOCHER教授的卓越研究，特别是DPP4抑制剂在肾脏疾病的研究，获得了勃林格殷格翰医药集团的多个研究基金作为奖励。

代表性学术论文：

1. Hocher B, Thöne-Reineke C, Rohmeiss P, Schmager F, Slowinski T, Burst V, Siegmund F, Quertermous T,Neumayer HH, Bauer C, Schleuning WD, Theuring F. Endothelin-1 transgenic mice develop renal cysts, interstitial fibrosis and glomerulosclerosis but not hypertension.J Clin Invest 99; 1380-1389 (1997)

1. Hocher B, Slowinski T, Stolze T, Pleschka A, Neumayer HH, Halle H. Association of maternal G protein ß3 subunit 825T allele with low birthweight.Lancet, 355;1241-1242 (2000)

1. Fischereder M, Luckow M, Hocher B, Wüthrich RP, Rothenpieler U, Schneeberger H, Panzer U, Stahl R, Neumayer HH, Hauser IA, Budde K, Neumayer HH, Krämer BK, Land W, Schlöndorff D. Prolongation of renal transplant survival in patients lacking a functional CC chemokine receptor 5 (CCR5). Lancet 357; 1758-1761 (2001)

1. Pfab T, Slowinski T, Godes M, Halle H, Priem F, Hocher B.Low birth weight, a risk factor for cardiovascular diseases in later life, is already associated with elevated fetal glycosylated hemoglobin at birth. Circulation. 114(16):1687-92 (2006)

1. Mitrovic V, Seferovic P, Dodic, D,KrotinM,NeskovicA,DicksteinK, Devoogd H, Böcker C, Ziegler D, Godes M, Najow R, Essers H, Verboom C,Hocher B. Cardio-Renal Effects of the A1 Adenosine Receptor Antagonist SLV320 in Patients with Heart Failure.Circulation: Heart Failure2(6):523-31 (2009)

1. Nair AV^&,,Hocher B^&,Verkaart S, van Zeeland F, Pfab T, Slowinski T, Chen YP, Schlingmann KP, Schaller A, Gallati S, Bindels RJ, Konrad M, Hoenderop JG.Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy.Proc Natl Acad Sci U S A.(2012)^&,equal contributing first authors

1. Horikoshi M, ………………, Ong KK, Vollenweider P, van Duijn CM, Koppelman GH, Hattersley AT, Holloway JW,Hocher B, Heinrich J, Power C, Melbye M, Guxens M, Pennell CE, Bønnelykke K, Bisgaard H, Eriksson JG, Widén E, Hakonarson H, Uitterlinden AG, Pouta A, Lawlor DA, Smith GD, Frayling TM, McCarthy MI, Grant SF, Jaddoe VW, Jarvelin MR, Timpson NJ, Prokopenko I, Freathy RM. New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.Nat Genet.45(1):76-82. doi: 10.1038/ng.2477(2013)

1. Tsuprykov O, Ando R, Reichetzeder C, von Websky K, Antonenko V, Sharkovska Y, Chaykovska L, Rahnenfuhrer J, Hasan AA, Tammen H, Alter M, Klein T, Ueda S, Yamagishi S, Okuda S,Hocher B. The DPP4 inhibitorLinagliptin and the angiotensin II receptor blocker telmisartan show renal benefit by different pathways innon-diabetic rats with 5/6 nephrectomy. Kidney Int, 2016 May;89(5):1049-61. doi: 10.1016/j.kint.2016.01.016.

2. Hocher B, Tsuprykov O.Diabetic nephropathy: Renoprotective effects of GLP1R agonists and SGLT2 inhibitors.Nat Rev Nephrol. 2017 Dec;13(12):728-730.

1. Li J, Lu YP, Tsuprykov O, Hasan AA, Reichetzeder C, Tian M, Zhang XL, Zhang Q, Sun GY, Guo J, Gaballa MMS, Peng XN, Lin G, Hocher B.Folate treatment of pregnant rat dams abolishes metabolic effects in female offspring induced by a paternal pre-conception unhealthy diet.Diabetologia. 2018 Aug;61(8):1862-1876

专利（可选）：

1. NON-OXIDIZED,BIOLOGICAL ACTIVE PARATHYROID HORMONE DETERMINES MORTALITY IN，Country of Granting：USA，Owner：Franz Paul Armbruster, Berthold Hocher, Heinz Juergen Roth

2.Use of a dpp-4 inbitor in podocytes related disorders and/or nephrotic syndrome, Country of Granting：USA，Owner：Thomas Klein, Maximilian von EYNATTEN, Berthold Hocher, Michael Mark, Yuliya SHARKOVSKA, Less

3.Means and methods of measuring parathyroidhormone in patients suffering, Country of Granting：EU，Owner：Franz Paul Armbruster, Berthold Hocher, Hans Juergen Groen, Heinz Juergen Roth

4.MEANS AND METHODS OF MEASURING PARATHYROID HORMONE IN PATIENTS SUFFERING FROM OXIDATIVE STRESS, Country of Granting：USA，Owner：Franz Paul Armbruster, Berthold Hocher, Hans Juergen Groen, Heinz Juergen Roth