戴灿，博士，副研究员，副教授，硕士研究生导师

电子邮箱：daican@live.cn

研究生招生专业：遗传学

个人简介：2010年获中南大学遗传学博士学位，之后在中南大学和美国西北太平洋糖尿病研究所进行博士后训练，2016年至今在湖南师范大学附属光琇医院工作。主要从事体外受精-胚胎移植（IVF-ET）实验室工作以及生殖遗传疾病的诊疗及致病机制研究，主持国家自然科学基金青年项目1项，湖南省自然科学基金青年项目1项、面上项目1项、企业联合基金重点项目1项，中信湘雅生殖与遗传专科医院中青年骨干项目1项。以第一作者及通讯作者（含并列）在J Biol Chem、Genetics in Medicine、Human Reproduction等领域知名期刊发表论文10篇。

代表性论文

(1)Jing Dai^{#, *}; Yueren Wu^#; Jianfang Che; Shuoping Zhang; Yifan Gu; Fei Gong;Can Dai*; Ge Lin*. Fertilization Failure Assay Identifies Stage-Specific Arrests in Couples with Total Fertilization Failure.Mol Hum Reprod.2026 Jan 7;32(1).

(2)Jian-Fang Che^#, Hui-Xia Wu^#, Si-Cong Zeng, Yue-Ren Wu, Jing Dai, De-Hua Cheng, Fei Gong, Guang-Xiu Lu, Ge Lin* andCan Dai*.Defects in phospholipase C zeta cause polyspermy and low fertilization after conventional IVF: not just ICSI failure.Asian Journal of Andrology.2024 Mar 1;26(2):175-182. doi:10.4103/aja202355. Epub 2023 Nov 17.

(3)Huixia Wu, Jianfang Che, Wei Zheng, Dehua Cheng, Fei Gong, Guangxiu Lu, Ge Lin*,Can Dai*. Novel biallelic ASTL variants are associated with polyspermy and female infertility: A successful live birth following ICSI treatment.Gene, Epub 2023 Aug 26; 887:147745.

(4)Yueren Wu#, Sicong Zeng#, Congxiu Miao, Huixia Wu, Xiaoming Xu, Liansheng Chen, Guangxiu Lu, Ge Lin*,Can Dai*. A 1-kb human CDCA8 promoter directs the spermatogonia-specific luciferase expression in adult testis.Gene, 2023 May 25; 866:147350.

(5)Jianmin Hu^#, Jin Li^#,Can Dai^#, Jinlin Ren, Wenru Yang, Caixia He, Fei Meng, Congling Dai, Sicong Zeng. HES1 deficiency impairs development of human intestinal mesenchyme by suppressing WNT5A expression.Biochem Biophys Res Commun, 2023 May 7; 655:50-58.

(6)Caixia He, Xiaorui Zhang, Jin Li, Conglin Dai, Siqi Wang,Can Dai*, Sicong Zeng*. Low-dose telomerase is required for the expansion and migration of placental mesenchymal stem cells.Biochem Biophys Res Commun, 2022 Dec 25;636(Pt 2):40-47.

(7)Yongzhe Chen, Zesong Wang, Yueren Wu, Wenbin He, Juan Du, Sufen Cai, Fei Gong, Guangxiu Lu, Ge Lin* andCan Dai*. A novel Heterozygous ZP3 deletion associated with empty follicle syndrome and abnormal follicular development.Front Genet, 2021 May 19.

(8)Can Dai^#*, Yongzhe Chen^#, Liang Hu, Juan Du, Fei Gong, Jing Dai, Shuoping Zhang, Mingyi Wang, Jing Chen, Jing Guo, Wei Zheng, Changfu Lu, Yueren, Wu, Guangxiu Lu, and Ge Lin*. ZP1 mutations are associated with empty follicle syndrome: evidence for the existence of an intact oocyte and a zona pellucida in follicles up to the early antral stage.Human Reproduction.2019 Nov 1;34(11):2201-2207.

(9)Can Dai^#, Liang Hu^#, Fei Gong^#, Yueqiu Tan, Sufen Cai, Shuoping Zhang, Jing Dai, Changfu Lu, Jing Chen, Yongzhe Chen, Guangxiu Lu, Juan Du*, Ge Lin*. ZP2 pathogenic variants cause in vitro fertilization failure and female infertility.Genetics in Medicine.2019 Feb;21(2):431-440.

(10)Can Dai^#, Cong-Xiu Miao^#, Xiao-Ming Xu, Lv-Jun Liu, Yi-Fan Gu, Di Zhou, Lian-Sheng Chen, Ge Lin, Guang-Xiu Lu. Transcriptional Activation of Human CDCA8 Gene Regulated by Transcription Factor NF-Y in Embryonic Stem Cells and Cancer Cells.Journal of Biological Chemistry.2015 Sep; 290(37): 22423~22434.