姓名：任凯群

照片：

职称：副教授

职务：医学院实验中心副主任

专业：免疫学，

联系电话：0731-88912434（Office）；15116261816(Cell phone)

电子邮箱：kaiqunren@hunnu.edu.cn

通讯地址：湖南省长沙市岳麓区桐梓坡路371号，

湖南师范大学医学院仁医楼A栋406室，邮编：410013

简介：博士，副教授，硕士生导师，南京大学遗传学博士，美国明尼苏达大学医学院访问学者。湖南师范大学医学部实验动物中心主任，从事实验动物科研工作23年，从事实验动物教学工作14年，培养硕士研究生6人。主持或参与国家自然科学基金项目2项，主持湖南省自然科学基金项目2项，湖南省教育厅重点1项。以通讯作者或第一作者身份发表SCI论文20余篇。申请或获国家发明专利2项。国家自然科学基金涵审专家，湖南省实验动物领域专家，湖南省实验动物伦理审核专家。

主持科研项目：

1，KCTD10通过Notch信号通路调控肝干细胞形成与分化的分子机制研究，国家自然科学基金，2016-2018（项目编号31501913）

2，KCTD10的表达调控对LCSCs自我更新能力以及药物增敏性研究，湖南省自然科学基金委，2016-2018（项目编号2015JJ6072）

3，湖南省自然科学基金，2020JJ4441，KCTD10对2型免疫反应（Th2）的调控研究， 2020-2022

4，湖南省教育厅重点项目，20A304，KCTD10的缺失对肠道表型及功能分析，2021-2023

5，横向课题，人脐带间充质干细胞和自然杀伤细胞外泌体抗皮肤糖化衰老及损伤修复研究，2024-2025

代表性学术论文

1.Yang Z, Yan F, Yuan J, Yang M, Wang J, You C, Ren K. Human umbilical cord mesenchymal stem cell-derived exosome ameliorate doxorubicin-induced senescence. Exp Cell Res. 2025 Feb 21;447(2):114450. doi: 10.1016/j.yexcr.2025.114450. Epub ahead of print. PMID: 39988122.

2.Wu J, Yang Z, Wang D, Xiao Y, Shao J,Ren K. Human Umbilical Cord Mesenchymal Stem Cell-derived Exosome Regulates Intestinal Type 2 Immunity. Curr Stem Cell Res Ther. 2024 May 22. doi: 10.2174/011574888X314032240429113240. Epub ahead of print. PMID: 38779734.(通讯作者)

3. Ma T, Wang D, Wu J, Xiao Y, Fan A, Cao X, Cao J,Ren K^#. KCTD10 functions as a tumor suppressor in hepatocellular carcinoma by triggering the Notch signaling pathway.Am J Transl Res.2023 Jan 15;15(1):125-137. PMID: 36777839; PMCID: PMC9908486. (通讯作者)

4.Zhao M,Ren K, Xiong X, Xin Y, Zou Y, Maynard JC, Kim A, Battist AP, Koneripalli N, Wang Y, Chen Q, Xin R, Yang C, Huang R, Yu J, Huang Z, Zhang Z, Wang H, Wang D, Xiao Y, Salgado OC, Jarjour NN, Hogquist KA, Revelo XS, Burlingame AL, Gao X, von Moltke J, Lin Z^#, Ruan HB^#. Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C.Immunity.2022 Apr 12;55(4):623-638.e5. doi: 10.1016/j.immuni.2022.03.009. Epub 2022 Apr 5. PMID: 35385697.

5.Wang XL, Cao XZ, Wang DY, Qiu YB, Deng KY, Cao JG, Lin SQ, Xu Y,Ren K^#. Casticin Attenuates Stemness in Cervical Cancer Stem-Like Cells by Regulating Activity and Expression of DNMT1.Chin J Integr Med.2023 Mar;29(3):224-232. doi: 10.1007/s11655-022-3469-z. Epub 2022 Jul 9. PMID: 35809177. (通讯作者)

6.Zhao M,Ren K, Xiong X, Cheng M, Zhang Z, Huang Z, Han X, Yang X, Alejandro EU, Ruan HB^#. Protein O-GlcNAc Modification Links Dietary and Gut Microbial Cues to the Differentiation of Enteroendocrine L Cells.Cell Rep.2020 Aug 11;32(6):108013. doi: 10.1016/j.celrep.2020.108013. PMID: 32783937; PMCID: PMC7457433.

7.Ren, K., Yuan, J., Yang, M., Gao, X., Ding, X., Zhou, J., Hu, X., Cao, J., Deng, X., Xiang, S. & Zhang, J. (2014) KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development,Plos One. 9, e112275.

8.Qu L, Liu FX, Cao XC, Xiao Q, Yang X,Ren K^#. Activation of the apoptosis signal-regulating kinase 1/c-Jun N-terminal kinase pathway is involved in the casticin-induced apoptosis of colon cancer cells.Exp Ther Med.2014 Nov;8(5):1494-1500. doi: 10.3892/etm.2014.1934. Epub 2014 Aug 26. PMID: 25289048; PMCID: PMC4186484.（通讯作者）

9.Jiang L, Cao XC, Cao JG, Liu F, Quan MF, Sheng XF,Ren K^#. Casticin induces ovarian cancer cell apoptosis by repressing FoxM1 through the activation of FOXO3a. Oncol Lett. 2013 May;5(5):1605-1610. doi: 10.3892/ol.2013.1258. Epub 2013 Mar 14. PMID: 23761826; PMCID: PMC3678892.（通讯作者）

10.Ren K, Cao XZ, Liu ZH, Guo H, Quan MF, Liu F, Jiang L, Xiang HL, Deng XY, Cao JG^#. 8-bromo-5-hydroxy-7-methoxychrysin targeting for inhibition of the properties of liver cancer stem cells by modulation of Twist signaling.Int J Oncol. 2013 Nov;43(5):1719-29. doi: 10.3892/ijo.2013.2071. Epub 2013 Aug 21. PMID: 23970349.

11.Ren K, Xian S, He F, Zhang W, Ding X, Wu Y, Yang L, Zhou J, Gao X, Zhang J^#. CK2 phosphorylates AP-2α and increases its transcriptional activity.BMB Rep.2011 Jul;44(7):490-5. doi: 10.5483/BMBRep.2011.44.7.490. PMID: 21777522.

12.Zhou, J.,Ren, K., Liu, X., Xiong, X., Hu, X. & Zhang, J^#. (2005) A novel PDIP1-related protein, KCTD10, that interacts with proliferating cell nuclear antigen and DNA polymerase delta,Biochimica et Biophysica Acta. 1729, 200-3.